ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Sila-Pharmaca, 22 Organophosphates with Anticholinesterase Activity and their Sila-AnaloguesThe organophosphates 1a-4a and their sila-analogues 1b-4b of the type R1R2P(O)-(p-OC6H4ElMe3) (El = C, Si) were synthesized. With regard to their anticholinesterase activity, the carbon compounds 1a-4a exhibit the same structure-activity relationships as the silicon compounds 1b-4b. The latter are more activ than the corresponding C-analogues.
Notes:
Die Organophosphorsäureester 1a-4a und ihre Sila-Analoga 1b-4b des Typs R1R2P(O)-(p-OC6H4ElMe3) (El = C, Si) wurden synthetisiert. Die Kohlenstoff-Verbindungen 1a-4a zeigen hinsichtlich ihrer Anticholinesterase-Aktivität die gleichen Struktur-Wirkungs-Beziehungen wie die Silicium-Verbindungen 1b-4b. Letztere sind jeweils wirksamer als die entsprechenden C-Analoga.
Additional Material:
4 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198119810306
