ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Hydrogen bonds as presented in Figure 2 cannot account for the enantioselective attack of cob(I)alamin (4(I)) or heptamethyl cob(I)yrinate (5(I)) on one of the two enantiotopic faces of the substrates. The attack of the strongly nucleophilic 3dz2 orbital is preferentially directed to the re-side of the starting materials with (Z)-configuration and leads, after the highly stereoselective reductive cleavage of the Co, C bond, to saturated products with (S)-configuration in varying enantiomeric excesses (see Schemes 1, 3 and Table 1).
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19800630633