ISSN:
1420-908X
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract MCD-peptide and its modified analogues have been tested for their histamine-releasing activity on mast cells and for the ability to inhibit vascular permeability in rat's skin. Reduction of disulphide bonds, modification of the basic lysine ɛ-NH2 groups and histidines in MCD-peptide suppressed its histamine-releasing action. Modification of the basic arginine guanidino groups did not alter this activity. MCD-peptide inhibited the vascular permeability induced by histamine and serotonin. Modification of MCD-peptide lysines and arginines abolished the inhibiting activity.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01991459