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The action of a calcitonin gene-related peptide antagonist in human skin (1993)

Hayes, N. A. ; Bunker, C. B. ; Marshall, I. ; [et al.]

Springer

Inflammation research 38 (1993), S. C212

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The CGRP antagonist, CGRP8-37, antagonized the ability of CGRP to increase blood flow in human skin and cause erythema. The mechanism of the antagonist effect of CGRP8-37 on the CGRP-induced erythema was an increase by the antagonist of the rate of decay of the CGRP-induced erythema. Since CGRP8-37 activates rat peritoneal mast cells to release their granular contents, we conclude that the degradation of CGRP by protease released from skin mast cells by CGRP8-37. It was not possible to demonstrate any antagonistic effect of CGRP8-37 on the CGRP receptor mediating increased blood flow in human skin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01996463

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