ISSN:
1420-908X
Keywords:
Key words: Cyclosporine A — Oxidative stress — Heart — Liver — Kidney
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Objective and Design: The study was designed to elucidate whether cyclosporine A (Cy A) induces oxidative stress in heart, liver and kidney.¶Material and Treatment: Male Wistar rats were treated with NaCl (n = 7), cremophor (vehicle for Cy A; n = 7) and 30 mg/kg b.w. Cy A in cremophor (n = 7) daily for 4 weeks.¶Methods: Oxidized (GSSG) and reduced (GSH) glutathione, lipid peroxides and superoxide dismutase were measured in the organs.¶Results: Increases in GSSG [nmol/mg prot.] and a compensatory rise in total GSH [nmol/mg prot.] indicating Cy A-induced oxidative stress were found in kidney (0.39 ± 0.09 vs. 0.47 ± 0.14 vs. 0.64 ± 0.18; 20.71 ± 3.86 vs. 21.07 ± 3.86 vs. 28.14 ± 3.37) and liver (0.51 ± 0.11 vs. 0.51 ± 0.09 vs. 0.65 ± 0.25; 33.35 ± 5.06 vs. 32.88 ± 5.12 vs. 44.12 ± 6.06) but not in heart.¶Conclusion: Cy A-induced oxidative stress may contribute to the hepatotoxicity and nephrotoxicity of this drug. After heart transplantation, accelerated allograft atherosclerosis limits transplantation success. We did not find any evidence that Cy A induces oxidative stress in the heart which might favour atherogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000110050223
