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Does the gastric mucosa contain inhibitory histamine H1-receptors? (1979)

Albinus, M. ; Malinski, S.

Springer

Inflammation research 9 (1979), S. 76-77

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Conclusion From the results it is concluded that in contrast to data reported in the literature, in cats histamine, dimaprit and tolazoline produce an identical acid response and differ only in their affinity to the histamine H2-receptor. The effects of mepyramine and phenoxybenzamine do not indicate the presence of H1-receptors, which is confirmed by missing inhibitory effects of PEA. The effects of the former two, however, suggest that reversal of the histamine dose-response curve is caused by histamine-released catecholamines which are prevented from being released by mepyramine and blocked in their peripheral action by phenoxybenzamine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02024124

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