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Lipoperoxide formation in the retina in ocular siderosis (1976)

Hiramitsu, T. ; Majima, Y. ; Hasegawa, Y. ; [et al.]

Springer

Cellular and molecular life sciences 32 (1976), S. 1324-1325

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Insertion of iron nail into the vitreous cavity provoked the formation of lipoperoxide in the retina. In accord with the increase in lipoperoxide in the retina, ERG began to decrease. In vitro experiment using isolated retina, lipoperoxide was found to be increased in the presence of ferric or ferrous ions, while it was inhibited by adding antioxidants or ethylenediamine tetraacetate. From these results, direct cause of retinal degeneration in siderosis could be ascribed to the formation of lipoperoxide by iron-ions liberated from the piece of iron, resulting into the degeneration of the visual cell layers of the retina.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01953119

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