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Structural alterations in rat kidney proximal tubules perfused with fresh autologous serum (1983)

Sato, K. ; Bentzel, C. J.

Springer

Cellular and molecular life sciences 39 (1983), S. 394-396

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Two min of intraluminal perfusion of the rat proximal tubules with autologous serum induced marked ultrastructural alterations including extensive cytoplasmic vesiculation due to swelling of rough endoplasmic reticulum cisternae and occasional extrusion of nuclei and cytoplasm into the lumen. Within 4 min pronounced vesiculation of mitochondria was observed. These findings are consistent with the notion that serum-induced inhibition of proximal tubular fluid absorption is due to cell lysis, presumably mediated by complement activation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01963143

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