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Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells (1994)

Graaf, T. W. ; Peters, G. J. ; Dijk, W.

Springer

Clinical & experimental metastasis 12 (1994), S. 134-142

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ISSN: 1573-7276

Keywords: antimetabolites ; cell cycle ; glycosylation ; invasion ; L1210

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Pretreatment of murine leukaemia L1210 cells with non-lethal concentrations of various antimetabolites increased thein vitro invasive capacity of these cells into monolayers of rat embryo fibroblasts. The increase in invasive capacity was partly correlated with the induced cell cycle arrest. The concomitant increase in cell surface fucosylation and inhibition of invasion with sulphate indicate a role for glycoproteins in this process. Our results suggest that treatment with antimetabolites may lead to a more aggressive phenotype by altering cell surface properties.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01753980

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