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Disposition and dosage regimen of cephaloridine in calves (1989)

Chaudhary, R. K. ; Srivastava, A. K.

Springer

Veterinary research communications 13 (1989), S. 325-329

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ISSN: 1573-7446

Keywords: blood ; cattle ; cephaloridine ; chemotherapy ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg. The absorption halflife, climination halflife, apparent volume of distribution and total body clearance were 0.107±0.025 h, 2.08±0.14 h, 0.70±0.07L kg-1 and 235.8±21.9 ml kg-1 h-1, respectively. Therapeutic plasma levels (≥1 μg/ml) were maintained for up to 7 h. A satisfactory intramuscular dosage regimen for cephaloridine in calves would be 10 mg/kg repeated at 8 h intervals.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00420839

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