ISSN:
1573-7446
Keywords:
blood
;
buffalo
;
chemotherapy
;
gentamicin
;
pharmacokinetics
;
urine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The disposition kinetics and urinary excretion of gentamicin sulphate were studied in young buffalo bulls following a single intramuscular administration of the drug at 5 mg kg-1 body weight. The time course of the serum gentamicin concentration was adequately described by the one-compartment open model. The values of the absorption and elimination halflives were 12.2±2.2 and 167.0±29.7 min respectively. The apparent volume of distribution was 0.29±0.01 L kg-1. During the first 12 h, 63% of the total administered dose was excreted in urine. On the basis of the kinetic data, a satisfactory intramuscular dosage regimen for gentamicin sulphate would be at least 6 mg kg-1 body weight repeated at 8 h intervals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00420840
