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Epsilon-Aminocaproic acid therapy in ulcerative colitis (1973)

Mowat, N. A. G. ; Douglas, A. S. ; Brunt, P. W. ; [et al.]

Springer

Digestive diseases and sciences 18 (1973), S. 959-965

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ISSN: 1573-2568

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A double-blind cross-over trial of the effect of Epsilon-Aminocaproic acid (EACA) versus placebo on gastrointestinal blood loss in 13 patients with proctocolitis showed no statistically significant reduction in blood loss recorded by the disappearance rate, as detected by whole-body monitoring of parenterally administered59Fe. Moreover, there was poor correlation between sigmoidoscopic findings, using a standard grading, and estimated colonic blood loss. Patients with severe proctocolitis were excluded from the trial. This is the first reported controlled trial of the effect of EACA on blood loss in proctocolitis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01072440

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