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Molecular Steps of Cell Suicide: An Insight into Immune Senescence (2000)

Gupta, Sudhir

Springer

Journal of clinical immunology 20 (2000), S. 229-239

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ISSN: 1573-2592

Keywords: Aging ; apoptosis ; TNF receptor ; Fas ; Fas ligand ; mitochondria

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mitochondrial pathways of apoptosis in general are reviewed. In particular, the role of apoptosis in T-cell immune senescence is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006653917314

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