ISSN:
1572-8870
Keywords:
Monoamineplatinum(II) complexes
;
polyaspartamides
;
water-soluble conjugates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In continuation of earlier work in this laboratory comprising the synthesis of water-soluble polyaspartamide-monoamineaquadichloroplatinum conjugates as potential antineoplastic agents, the presently described project is concerned with related conjugates in which the same type of monoamineplatinum complex unit is bound to polyaspartamide carriers via main chain-attached poly(ethylene oxide) (PEO) spacers introduced here in order to improve certain biomedical performance features. The conjugates are synthesized by aqueous-phase platination of amine terminals on the PEO side chains of the carriers, brought about by treatment with tetrachloroplatinate(II) anion under closely controlled conditions of time, temperature, and acidity, followed by dialysis. The target polymers, separated by freeze-drying, are completely water soluble upon isolation, yet undergo slow intermolecular interaction in the solid state with a gradual loss of solubility unless stored in (frozen) aqueous solution at −30°C.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021492211906
