ISSN:
1573-7373
Keywords:
brain neoplasm
;
amonafide
;
chemotherapy
;
glioma
;
astrocytoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Amonafide, a novel imide derivative with broad preclinical antitumor activity, achieves significant cerebrospinal fluid levels in animal models. In order to test its antitumor activity in patients with recurrent diffuse infiltrative glioma of the astrocytic and oligodendroglial type, we performed a phase II clinical trial. Of the 22 eligible and evaluable patients treated, 2 (9%) experienced tumor regression lasting more than one year. No other patients experienced tumor regression; one remained stable more than six months. Toxicities consisted primarily of myelosuppression, vomiting, and venous irritation at the infusion site. We conclude that amonafide has minimal activity in recurrent glioma patients. Further investigations are not warranted in this study population.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01058464