ISSN:
1573-6903
Keywords:
S-100 protein
;
LTP
;
hippocampus
;
cAMP
;
protein kinases
;
gene transcription
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Long term potentiation (LTP) was induced in the CA1 region of rat hippocampal slices by tetanization of the Schaffer collaterals. Local pretreatment of CA1 with serum of rabbits immunized against S-100 prevented the potentiation. However, treatment of the slices with a membrane permeant cAMP analogue, such as 8-Br-cAMP, could protect against the blocking effect of anti S-100 serum. We suggest that in the rat endogenous S-100b is involved in transduction mechanisms during LTP induction, via its ability to stimulate adenylate cyclase. Possible mechanisms of this action are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007524412366