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  • 1
    Electronic Resource
    Electronic Resource
    Increase of Cerebral Phosphocreatine in Normal Rats after Intracerebroventricular Administration of Creatine (2000)
    Springer
    Neurochemical research 25 (2000), S. 1493-1495 
    Details
    ISSN: 1573-6903
    Keywords: In vivo ; creatine ; phosphocreatine ; osmotic pumps ; intracerebroventricular administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracerebroventricular (ICV) administration of creatine increased cerebral phosphocreatine in normal rats by 67%, the highest increase so far reported in an in vivo model. We used osmotic minipumps (Alzet, Palo Alto, CA, USA) to administer creatine, 0.5mM, to the lateral ventricle at the rate of 10 μl/h for 3 days. Brain phosphocreatine in saline-treated controls was 33 ± 17 μM/g protein (mean ± SD, N = 9). In creatine-treated rats (0.5 mM for 3 days) such content was 55 ± 17 μM/g protein (mean ± SD, N = 7). This difference is statistically significant (p = 0.02, t-test). The increase we found in cerebral phosphocreatine is of an order of magnitude comparable to the increase previously found in in vitro experiments, and may be effective in protecting brain tissue from ischemic damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007628226044
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antiserum Against S-100 Protein Prevents Long Term Potentiation Through a cAMP-Related Mechanism (2000)
    Springer
    Neurochemical research 25 (2000), S. 541-545 
    Details
    ISSN: 1573-6903
    Keywords: S-100 protein ; LTP ; hippocampus ; cAMP ; protein kinases ; gene transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long term potentiation (LTP) was induced in the CA1 region of rat hippocampal slices by tetanization of the Schaffer collaterals. Local pretreatment of CA1 with serum of rabbits immunized against S-100 prevented the potentiation. However, treatment of the slices with a membrane permeant cAMP analogue, such as 8-Br-cAMP, could protect against the blocking effect of anti S-100 serum. We suggest that in the rat endogenous S-100b is involved in transduction mechanisms during LTP induction, via its ability to stimulate adenylate cyclase. Possible mechanisms of this action are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007524412366
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy for recurrent or persistent squamous-cell cervical cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 1171-1174 
    Details
    ISSN: 1569-8041
    Keywords: cervical cancer ; chemotherapy ; cisplatin ; ifosfamide ; paclitaxel ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The results of salvage chemotherapy for recurrent or persistent squamous-cell cervical cancer are unsatisfactory. Cisplatin and Ifosfamide are effective compounds in cervical cancer. Paclitaxel has recently been tested with promising results. The aim of this study was to assess the efficacy of a combination of paclitaxel, ifosfamide and cisplatin (TIP) for persistent/recurrent squamous-cell cervical carcinoma in a phase II trial. Patients and methods: Forty-five women were treated with the TIP regimen. Thirty-one had received prior irradiation. Paclitaxel was given at a dose of 175 mg/m2, ifosfamide at a dose of 5 g/m2, and cisplatin at a dose of 75 mg/m2 (50 mg/m2 in irradiated patients) at three-week intervals. Results: We observed 15 clinical complete responses, 15 partial responses, 9 stable diseases and 6 progressions. The objective response rate was 67% (95% confidence interval: 51%–81%). Ten complete responders underwent subsequent surgery and seven had pathology-defined complete responses (two in irradiated areas). The response rate was 52% in irradiated and 75% in non-irradiated areas. The median survival for non-responders is 6 months, 9+ month for partial responders and 13+ for complete responders. The most relevant side effect was myelotoxicity, with 91% of patients experiencing grade 3–4. One woman had life-threatening toxic effects. Conclusions: This combination is highly effective for salvage treatment in non-irradiated patients. For irradiated women the response rate is higher than that observed with other regimens but further investigation is warranted. The toxicity is relevant but adequate hydration and prolonged infusion of ifosfamide make it acceptable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008362814642
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bannwarth syndrome: report of two cases (1983)
    Springer
    Neurological sciences 4 (1983), S. 485-487 
    Details
    ISSN: 1590-3478
    Keywords: Bannwarth syndrome ; facial paralysis ; meningoradiculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sono descritti due casi di sindrome di Bannwarth, ben conosciuta nelle letterature mediche straniere ma non segnalata nella letteratura italiana.
    Notes: Abstract Report of two cases of Bannwarth syndrome, an apparently neglected condition both in the Italian and in the English literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02125631
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    Paper (German National Licenses)
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