ISSN:
1432-1440
Keywords:
Thyroid lymphoma
;
B-CLL
;
Centroblastic lymphoma
;
Immunohistochemistry
;
Gene rearrangement analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 67-year-old woman suffering since 5 years from a so far nontreated B-CLL underwent hemithyroidectomy for a rapidly enlarging tumor. Histologically, the coincidence of a centroblastic lymphoma and thyroidal infiltration by the CLL was diagnosed. Immunohistology revealed typical immunoprofils for both, B-CLL and centroblastic lymphoma on the background of B cell differentiation antigens. The bitypical immunoglobulin light chain expression — λ on the B-CLL cells and κ on the centroblasts — suggested biclonality. This was confirmed by gene rearrangement analysis of peripheral leukemia cells and tumor tissue. Thus, the final diagnosis of a primary thyroidal lymphoma of the centroblastic type (stage IE) arising independently from a preexisting B-CLL was achieved. Consequently, the patient received local radiotherapy. In our opinion, the designation “Richter's Syndrome”, readily applied in the literature, is inappropriate for this tumor constellation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01726417
