ISSN:
1432-1440
Schlagwort(e):
Allopurinol
;
Oxipurinol
;
Hydrochlorothiazide
;
Drug interaction
;
Kinetics
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The kinetics of allopurinol and hydrochlorothiazide were investigated in seven healthy male subjects during prolonged coadministration of two drugs. Subjects were maintained on an isoenergetic, purine-free formula diet with RNA supplementation for 24 days. Allopurinol (300 mg) was given orally on days 1–24. Hydrochlorothiazide (50 mg daily) was added to days 11–21. On day 43 a single oral dose of 50 mg hydrochlorothiazide was administered. Plasma concentration-time profiles of allopurinol and its main metabolite oxipurinol were obtained on days 1, 10, and 21; hydrochlorothiazide profiles were assessed on days 21 and 43. In addition, 24-h plasma concentrations of oxipurinol were measured repetitively, and 24 h urine samples were collected for the determination of allopurinol, oxipurinol, and hydrochlorothiazide. For oxipurinol, meanC max was not altered on hydrochlorothiazide treatment (13.8 ± 1.4 μg/ ml and 14.7 ± 2.6 μg/ml, respectively); mean AUC0–24 was 259 and 290 μg h−1 ml−1, respectively. The small difference in AUC0–24 values does not explain the increase in plasma uric acid concentration during hydrochlorothiazide treatment, nor do the variations in allopurinol and hydrochlorothiazide kinetics.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00577759
