ISSN:
1432-0428
Keywords:
Keywords Essential hypertension
;
endothelium
;
endothelins
;
cardiovascular risk.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Circulating endothelin-1 concentration was evaluated in 93 lean patients with essential hypertension, of whom 16 had impaired glucose tolerance and hyperlipidaemia, 25 had impaired glucose tolerance, 28 had hyperlipidaemia and 24 had no metabolic abnormalities; we also studied 22 control subjects. All groups were age- and sex-matched. Plasma endothelin-1 levels were higher (p 〈 0.05) in hypertensive patients with impaired glucose tolerance and hyperlipidaemia than in the remaining groups, and were directly correlated with fasting insulin levels (r = 0.506, p = 0.045). Therefore, circulating endothelin-1 concentrations are elevated in hypertensive patients with a high-risk profile due to the presence of metabolic abnormalities, and might favour the development of vascular damage. [Diabetologia (1997) 40: 100–102]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001250050649
