ISSN:
1432-1912
Keywords:
Anaphylatoxin
;
Anaphylaxis
;
Histamine
;
Catecholamines
;
β-Adrenergic Blockade
;
Anaphylatoxin
;
Anaphylaxie
;
Histamin
;
Katechol amine
;
β-adrenergische Blockade
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. In the heart lung preparation (HLP) of the guinea pig 2.5 ml rat serum anaphylatoxin (AT) released approximately ten times less histamine than was released by 5 mg ovalbumin in the sensitized HLP. In intact animals the plasma histamine increase caused by 5 ml/kg AT was not significantly different from that caused by 10 mg/kg ovalbumin. It is supposed that in AT shock extrapulmonary sources contribute to plasma histamine more than in anaphylactic shock. 2. Mepyramine maleate (40 μg/ml blood) did not significantly reduce the bronchospasm caused by AT in HLP except when a very high AT dose (0.3 ml/ml) was given. In the intact animal, mepyramine lowered the AT-induced bronchospasm by 50–65%. This effect of mepyramine is completely abolished byβ-adrenoceptive receptor blockade. 3. It is concluded that the prevalence of histamine effects in AT shock in vivo, as documented by the life saving effect of antihistamines, is due to 2 facts: influx of histamine from the organs other than the lung, and preferential antagonism by catecholamines of such shock mechanisms which are not based on histamine release.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997283
