ISSN:
1432-1912
Schlagwort(e):
β-Adrenoceptor antagonists
;
(+)- and (−)-Configuration
;
Membrane stabilizing activity
;
Glucose tolerance test
;
Insulin
;
Glucose
;
Insulin-glucagon ration
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The relevance of the steric configuration to the effects of two non-selective β-adrenoceptor antagonists without intrinsic sympathomimetic activity (+)- and (−)-bupranolol (10 and 50 μg/kg i.v.) and (+)- and (−)-propranolol (100 and 500 μg/kg i.v.) on the i.v. glucose tolerance test (IVGTT) were investigated in conscious, normoglycemic dogs. The effects of the β-adrenoceptor antagonists on plasma glucose, and insulin levels and insulin-glucagon ratio following IVGTT were evaluated by calculating the respective areas under the curve (AUC). The AUC values for plasma glucose were significantly increased by the (−)-configuration of both β-adrenoceptor antagonists. In the (+)-configuration only propranolol (500 μg/kg i.v.) increased the AUC value for plasma glucose significantly. The AUC values for plasma insulin and also for the plasma insulinglucagon ratio were significantly decreased by (−)-propranolol (500 μg/kg i.v.) and by (−)-bupranolol (10 and 50 μg/kg i.v.). Thus the impairment of glucose tolerance, due to suppression of the plasma insulin level, depends mainly on the β-adrenoceptor antagonistic activity of the (−)-configuration.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00647837
