ISSN:
1432-2072
Keywords:
(Δ 1-THC)
;
Cannabidiol (CBD)
;
Open field behavior
;
Psychotomimetic action
;
Circling behavior
;
Rotation
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Relatively high dosages of Δ 1-tetrahydrocannabinol (Δ 1-THC) markedly suppressed almost all normally occurring behavioral elements in rats as observed in both a small and a large open field. This effect persisted following repeated treatment and testing for 3 consecutive days. The psychotropically inert but related compound cannabidiol (CBD) did not suppress behavior, but in contrast had a mild activating effect. Both compounds decreased defecation during the test procedure. In addition, Δ 1-THC, but not CBD, induced a bizarre circling and turning response, that was evident over all 3 test days and occurred even when the rats were deeply sedated. It is suggested that an analysis of this phenomenon may be useful in measuring the psychotominetic action of Δ 1-THC and similar compounds in rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431466
