ISSN:
1432-2072
Keywords:
Ro 15-1788
;
Benzodiazepine antagonist
;
Behaviour
;
Electrophysiology
;
Biochemistry
;
Neurology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The imidazodiazepine Ro 15-1788 is a benzodiazepine receptor antagonist that was initially reported to be lacking in intrinsic activity in a variety of test situations in which benzodiazepine-like effects can be identified. However, many recent studies have shown that this compound does indeed have intrinsic activity in a variety of behavioural, neurological, electrophysiological and biochemical preparations in both animals and man. The purpose of the present review is firstly to describe these intrinsic actions, and secondly to consider to what extent these intrinsic actions of Ro 15-1788 have implications for current concepts of the functioning of the benzodiazepine receptor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310505
