ISSN:
1432-2072
Keywords:
State-dependency
;
Chlordiazepoxide
;
Method
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A state-dependency procedure is described in which changes from the chlordiazepoxide state yield a robust and dose-dependent response decrement in rats. The format of data that are obtained with this procedure permits that the response decrement following a state change be defined accurately in individual animals, and that transfer be quantified. Dose-response studies revealed 13 (7.4–22) mg/kg to be the ED50 of chlordiazepoxide at which transfer occurred in animals that had acquired the response with 40 mg/kg chlordiazepoxide; the ED50 acquisition dose of chlordiazepoxide at which transfer to saline failed to occur was 3.7 (2.2–6.4 mg/kg).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00172887
