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Design and operating criteria for hollow fiber bioreactors (1996)

Sardonini, C. ; DiBiasio, D.

Springer

Bioprocess engineering 15 (1996), S. 327-330

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ISSN: 0178-515X

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Notes: Abstract We have analyzed the design and operation of hollow fiber bioreactors for cell culture on the basis of cell growth efficiency and non-uniform fiber spacing. Operating diagrams are presented that describe reactor performance as a function of important operating variables like oxygen concentration and the fiber packing density. The diagrams allow one to find the best set of operating conditions for a fixed reactor design, or to rationally adjust the design parameters for fixed operating conditions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004490050276

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