ISSN:
1432-1106
Keywords:
Hippocampus
;
Experimental epilepsy
;
Paroxysmal depolarization shift
;
Afterpotential
;
Penicillin
;
Ca2+-activated potassium
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Penicillin-induced paroxysmal depolarization shifts (PDS) are followed by prolonged afterhyperpolarizations of about 2 seconds duration. Intracellular injection of EGTA blocked a late component of the afterhyperpolarizations; an early one lasting up to one second was only slightly reduced by EGTA. It is concluded that afterhyperpolarizations following penicillininduced PDS comprise different components: an initial one lasting up to one second which is not Ca2+-dependent and a slow one lasting up to two seconds which is caused by a Ca2+-dependent K+ current.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00230253
