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Plasma timolol levels after oral and intravenous administration (1978)

Else, O. F. ; Sorenson, H. ; Edwards, I. R.

Springer

European journal of clinical pharmacology 14 (1978), S. 431-434

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ISSN: 1432-1041

Keywords: Timolol ; pharmacokinetics ; oral and intravenous dosing

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volume of distribution was 3.5 l/k. It is suggested that timolol is little affected by the ‘first pass effect’, even though there is marked interindividual variation in availability and peak plasma level.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00716385

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