ISSN:
1432-1041
Keywords:
sotalol
;
hydrochlorothiazide
;
pharmacokinetics
;
moderate renal failure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Decreased elimination of a combined formulation of Sotalol (160 mg) and hydrochlorothiazide (25 mg) was found in patients with moderate renal insufficiency. Very slight accumulation of sotalol and hydrochlorothiazide was observed, so it appears unnecessary to reduce the dosage in patients with a creatinine clearance of 30 ml/min or more.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542176