ISSN:
1432-1041
Keywords:
Fansimef
;
phagocytosis
;
malaria treatment
;
neutrophil function
;
monocyte function
;
chemotaxis
;
oxidative metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of Fansimef, a recently registered triple combination of mefloquine, sulfadoxine and pyrimethamine (10:25:1) on human peripheral blood polymorphonuclear and mononuclear leucocyte function was studied. At clinically obtainable concentrations Fansimef had no effect on leucocyte viability, it did inhibit neutrophil chemiluminescence and it had no effect on other major functions, such as chemotaxis, NBT reduction, superoxide production, phagocytosis and the bactericidal activity of phagocytic cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00635897
