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Experimental transmission of human subacute spongiform encephalopathy to small rodents (1981)

Tateishi, J. ; Doi, H. ; Sato, Y. ; [et al.]

Springer

Acta neuropathologica 53 (1981), S. 161-163

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ISSN: 1432-0533

Keywords: Subacute spongiform encephalopathy ; Creutzfeldt-Jakob disease ; Experimental transmission ; Small rodents ; Transmissible agent

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Further experimental transmission of Creutzfeldt-Jakob disease (CJD) from three patients to mice and rats was carried out successfully. The clinical signs and pathologic features of spongiform encephalopathy transmitted to animals were much the same as in previous experiments, except that distribution of the lesions in the mice differed with each inoculated material taken from the patients. These observations suggest the multiplicity of CJD agents, as in the case of scrapie agents.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00689997

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