ISSN:
1432-0533
Keywords:
Avian sarcoma virus
;
Brain tumor
;
Glial fibrillary acidic protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The immunohistochemical localization of glial fibrillary acidic protein (GFAP) was studied by the peroxidase-antiperoxidase (PAP) method in avian sarcoma virus (ASV)-induced brain tumors in hamsters. One hundred twenty-four tumors including 54 astrocytomas, 64 pleomorphic gliomas, five sarcomas, and one unclassified tumor were stained with anti-GFAP serum. A positive immunostaining was seen in astrocytomas and in pleomorphic gliomas. Sarcomas and an unclassified tumor were negative. These results confirmed that a majority of ASV-induced brain tumors contained neoplastic glial cells, and further suggested that the astrocyte is a main target cell of ASV in the experimental neuro-oncogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00690993
