ISSN:
1432-0533
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Single i.v. administration ofCorynebacterium parvum 5 days before i.v. injection of 106 tissue cultured syngeneic schwannoma cells in Lewis rats resulted in extension of survival time (P〈0.05). There was a significant decrease in metastatic tumor incidence for lung, heart, and kidney and decreased lung tumor growth with approximately 50% of the lung tumor burden of untreated controls (P〈0.05). Rats treated similarly withC. parvum 10 days after tumor cell injection showed no enhanced survival; to the contrary, their survival was shortened. Moreover, tumor incidence in the post-treated group was not significantly different from the control but significantly increased in comparison to the pretreated group. Enhanced lung tumor growth resulted in a final tumor burden about twice that of untreated controls (P〈0.05).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688951
