ISSN:
1432-0533
Keywords:
Electron microscopy
;
Factor VIII
;
Glial fibrillary acidic protein
;
Hemangioblastoma
;
Tissue culture
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The histogenesis of stromal cells in capillary hemangioblastoma has been the subject of debate. The light and electron microscopic studies of hemangioblastomas presented here showed pericytic and leiomyoblastic features in stromal cells. Cells cultured by the monolayer method showed similar features to those of the original tumors. Immunohistochemical studies for glial fibrillary acidic protein and factor VIII/von Willebrand factor indicated that stromal cells were antigenically distinct from astrocytes and endothelial cells. These findings suggest that stromal cells are closely related to pericytes and smooth muscle cells, and support Rhodin's speculation that pericytes serve as a precursor to smooth muscle cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688262
