ISSN:
1432-0533
Keywords:
Striatum
;
Parkinsonism-dementia complex on Guam
;
Met-enkephalin
;
Substance P
;
Striosomes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This report concerns a topographic immunohistochemcal analysis of Met-enkephalin (MEnk) and substance P (SP) expression in the striatum from seven patients with parkinsonism-dementia complex on Guam (PDC). The striatum of seven neurologically normal subjects served as controls. MEnk-positive striosomes were readily visualized in both the caudate nucleus and the putament of the PDC cases. Although the immunoreactivity was less than that of MEnk, SP-positive patches were detected in the PDC striatum. The patches were similar to those seen in the normal controls. These results provide additional evidence that the striatum and its efferent system appear to be preserved in patients with PDC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00334449
