ISSN:
1432-069X
Keywords:
Epidermal blister
;
Benzo(a)pyrene metabolism
;
Human genetics
;
Cancer susceptibility
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Benzo(a)pyrene (BP) metabolism has been studied in epidermal blisters maintained in a culture medium for 24 h and 48 h. The viability of the cells has been assayed by [3H]proline incorporation into proteins and by [14C]BP metabolism into unconjugated metabolites. A screen of BP metabolism in 19 individuals shows a great variation of basal epidermal activity. Induction of BP metabolism by the application of coal tar 24 h before the epidermal blister sampling, resulted in two- to eight-fold increase in BP metabolism. This induction is not increased when the coal tar application is repeated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00407747
