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The effect of topical cyclosporin A on the rabbit cornea (1986)

Behrens-Baumann, W. ; Theuring, S. ; Brewitt, H.

Springer

Graefe's archive for clinical and experimental ophthalmology 224 (1986), S. 520-524

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ISSN: 1435-702X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02154739

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