Electronic Resource
Springer
European journal of pediatrics
149 (1989), S. 96-103
ISSN:
1432-1076
Keywords:
DiGeorge sequence
;
Thymus
;
Thymic aplasia
;
Immunoglobulins
;
Cellular immunity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We present immunological in vitro data on a group of 16 patients with the DiGeorge sequence (DGS). Detailed tests gave evidence that the decrease in number and function of mature T-cells is closely correlated with phenotypic expression and represents a wide immunological spectrum ranging from normal function to severe combined immunodeficiency with B-cells. Careful immunological testing in DGS may help to plan therapeutic procedures (i. e. thymic factor therapy or bone marrow transplantation) may also have prognostic significance and help to gain insight into mechanisms operative in disturbances of T-cell regulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01995856
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