ISSN:
1432-1335
Keywords:
Aryl hydrocarbon hydroxylase
;
Cancer
;
Carcinogenesis
;
Smoking
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The levels of aryl hydrocarbon hydroxylase (AHH) inducibility were assessed in 173 patients with cancers statistically associated with smoking, i.e., squamous cell and transitional cell carcinomas, at various sites. In 34 patients with carcinomas of the oral cavity, 41 patients with laryngeal carcinomas, and 22 patients with pulmonary carcinomas there was a highly significant overrepresentation of high inducers, whereas 30 patients with carcinomas of the renal pelvis and ureter and 46 patients with urinary bladder carcinomas did not differ significantly in this respect from a control population comprising 92 subject with no history of neoplastic disease. The results add further support to the concept of AHH as a major activator of carcinogens belonging to the group of polycyclic aromatic hydrocarbons (PAH) when these affect·the oral cavity and/or the respiratory tract. The role of AHH in urothelial carcinogenesis seems to be less explicit.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00390459
