ISSN:
1432-1335
Keywords:
Lymphoid malignancies
;
Tumor necrosis factorα
;
Lymphotoxin
;
Transforming growth factorβ
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The expression of cytokine genes for tumor necrosis factorα (TNFα), lymphotoxin and transforming growth factorβ (TGFβ), all of which are known to suppress normal hematopoiesis, was investigated in 32 patients with lymphoid malignancies using Northern blot analysis. Messenger RNA (mRNA) for TNFα, lymphotoxin and TGFβ was detected in 9 cases, 2 cases and 7 cases, respectively. When the relationship between cytokine gene expression and surface phenotype was analyzed, the expression of CD19 correlated significantly with expression of the TNFα gene (P〈0.05). This suggests that B cell malignancies are likely to produce TNFα. When the hematological parameters of patients expressing and not expressing the gene were compared, the expression of TNFα mRNA was found to correlate with more profound anemia in acute lymphoblastic leukemia (P〈0.05). Both granulocyte and platelet counts were lower in patients expressing TNFα mRNA; however, the decreases were not significant. Neither lymphotoxin nor TGFβ gene expression correlated significantly with any hematological parameter.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01630720
