ISSN:
1617-4623
Keywords:
Key words Mitochondria
;
Processed pseudogenes
;
Human Tom20 gene
;
Import receptor
;
Retroposons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract We report the identification and characterization of Ψ3Tom20, a novel processed pseudogene of the human Tom20 (hTom20) gene, which is 96.2% similarity with the hTom20 cDNA and is 5′ and 3′ truncated. In addition, we present the complete characterization of Ψ1Tom20 and Ψ2Tom20, the two other recently reported members of this pseudogene family. Comparison of the sequences of Ψ3Tom20 with that of the previously reported Ψ2Tom20 revealed and corrected an error in the previously determined sequence of Ψ2Tom20. A detailed analysis of these three pseudogenes, including their flanking regions, is presented. It suggests they probably arose from mRNAs that were polyadenylated at different sites. Possible mechanisms involved in their integration as retroposons are also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004380051076
