ISSN:
1432-0517
Keywords:
Key words Experimental design
;
Analysis of variance (ANOVA)
;
Determination of uncertainties
;
Human serum
;
Cholesterol
;
Standard reference material
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Repeated subsampling or a hierarchical design of experiments combined with an analysis of variance (ANOVA) is demonstrated to be a useful tool in the determination of uncertainty components in amount-of-substance measurements. With the reference material of human serum as investigated here for total cholesterol, besides several in-laboratory sources of uncertainty, a vial-to-vial effect which can be regarded as an off-laboratory source was found to be significant. This knowledge might be essential when the material is used for calibration and for the self-assessment of a laboratory.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007690050204
