ISSN:
0942-0940
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The authors report a new experimental model for the study of hydrocephalus. Hydrocephalus was produced in C 57 black mouse by transplanting human glioma cultured cells. 20% of the animals developed hydrocephalus while the incidence of spontaneous hydrocephalus is only 1%. The transplanted cells disappeared within 72 hours. The mouse developed progressive hydrocephalus. There was no evidence of blockage of CSF pathways. The only abnormal microscopic finding was a scattered collection of lymphoid cells in some of the animals, which may be a hypersensitivity reaction to the cells. A similarly hypersensitive reaction to the foreign maternal protein which may enter the foetal circulation is suggested as the cause of hydrocephalus in some of the cases of congenital hydrocephalus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01402294
