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Ultrastructural study on the sequence of human cytomegalovirus infection in human diploid cells (1973)

Iwasaki, Y. ; Furukawa, T. ; Plotkin, S. ; [et al.]

Springer

Archives of virology 40 (1973), S. 311-324

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ISSN: 1432-8798

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The sequence of human CMV infection in WI 38 cells at high input multiplicity was studied by electron microscopy. The majority of entering virus particles were degraded within the cytoplasmic vacuoles but few particles released their capsids into the cytoplasm. Unenveloped particles with a distinct core were observed to persist over a period of 24 hours post-infection. Virus particles in the nucleus were only detectable 48 hours post-infection and thereafter. Process of formation and segregation of primary lysosome-like dense bodies was observed in association with the termination of the virus assembly cycle.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01242551

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