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(n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma (1995)

Leichsenring, M. ; Kochsiek, U. ; Paul, K.

Oxford, UK : Blackwell Publishing Ltd

Pediatric allergy and immunology 6 (1995), S. 0

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ISSN: 1399-3038

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: It has been suggested that atopy is associated with an impairment in the δ6-desaturation of (n-6)-polyunsaturated fatty acids and subsequently low levels of eicosanoid precursors. To evaluate this hypothesis we analyzed the fatty acid composition of plasma phospholipids and plasma cholesterolest-ers in a well-defined group of children with atopic bronchial asthma (n = 17) and age-matched healthy controls (n = 10). Atopic children showed significantly higher levels of linoleic acid and lower proportions of arachidonic acid in plasma lipids. No differences were observed with respect to γ-lino-lenic acid (GLA) and dihomo-γ-linolenic acid (DHLA). It is concluded that there is no biochemical evidence for a δ6-desaturation defect in atopic children and therefore no justification for the supplementation of GLA and DHLA; e.g. by the use of evening primrose oil preparations.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1399-3038.1995.tb00287.x

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