ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
By means of a panel of monoclonal antibodies it is demonstrated that, in cultures of human peripheral blood mononuclear cells (PBMC) with the T-cell dependent (TD) antigen ovalbumin (OA), responding B ceils are activated from the resting Mate The differentiation of the activated B cells to high rate-secreting plasma blasts, however, is attested in an early activation phase, in which they can be detected at low rate-secreting plaque-forming cell. The arrest does not occur when stimulation with OA occurs in the presence of antigen-nonspecific activation and maturation factors, which are provided in the culture by the anamnestic response to the TD antigen tetanus toxoid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1988.tb02414.x
