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  • 1
    Electronic Resource
    Electronic Resource
    A Pyroninophilic Component in Pathological Serum Proteins and Urinary Proteins (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 60-60 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Yeoman2'3 applied this staining method to serum proteins and urinary proteins from patients with multiple myeloma. In each of the 11 cases examined, the abnormal protein fraction stained red-violet with pyronine -methyl green after paper electro-phoresis of both serum and urine. This staining ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/189060a0
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of So-called Atypical Macroglobulinæmia as an Atypical Form of β 2 A -Paraproteinæmia: a New Immunological Entity? (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 768-770 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Little is known as yet about the nature of these proteins. It was pointed out by Putnam2 that these rapidly sedimentating proteins are exclusively encountered in the case of so-called (3-myelomata. They differ from the p2M-macrglkulms m inimunological characteristics3. In sera from nine patients ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/189768a0
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  • 3
    Electronic Resource
    Electronic Resource
    Impact of mental stress on the immune response (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 18 (1991), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Psychosocial factors can influence immune functions: the brain intermediates between the outside world and the inside of the body. The functional interaction between the central nervous system and the immune system is effected by 2 different pathways: the nervous “wiring system” innervating lymphoid tissues and the “soluble connection” via the neuroendocrine system. The paper reviews data from the literature regarding changes in susceptibility to infections due to stressful conditions. Emphasis is given to information regarding infection of the oral cavity and the upper respiratory tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1991.tb02311.x
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  • 4
    Electronic Resource
    Electronic Resource
    Studies on Fd Fragments of Human Immunoglobulins (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Earlier studies on antisera against Fab of pooled human IgG and IgA myeloma proteins disclosed the presence of class-specific Fd antibodies, the demonstration of which required interaction of heavy and light chains. To extend our knowledge about the antigenic structure of the Fd fragment of human immunoglobulins, antisera were prepared in rabbits against γ chains of pooled IgG and of four IgG1 myeloma proteins, an Fdγ fragment and a cyanogen bromide-produced CH1 preparation of an IgG1 myeloma protein, and an Fdα fragment of an IgA1 myeloma protein. No antigenic determinants exclusively confined to the CH1 region of intact human IgG could be demonstrated with these antisera. The antigenic structure of CH1 in intact immunoglobulins may thus only be defined by light-chain-dependent determinants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02613.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ligands of Surface Ig Raise Cytoplasmic Free Ca++ in Human B Cells (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 22 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: With the use of the fluorescent Ca++ indicator Quin-2, we have measured changes in intracellular calcium levels in human B cells in response to anti-Ig antibodies, to Staphylococcus aureus (Staph) or to protein A. Cells of an Epstein-Barr virus-transformed μλ-carrying B-cell line, AZU-1, increased free cytosolic calcium after addition of anti-μ or anti-μ antibodies: F (ab′)2 fragments with anti-μ specificity were equally effective. Fab fragments of sheep anti-Ig antibodies only induced a rise in calcium levels after addition of a second anti-sheep Ig antiserum. Cross-linking of non-Ig surface determinants did not influence calcium homeostasis. The calcium channel blockers verapamil (100 μM). nifedipine (20 μM). and LaCl3 (200 μM) inhibited the anti-μ-induced calcium influx. Peripheral blood B cells reacted in essentially the same way in response to anti-μ antibodies. The B cell mitogens protein A and Staph also induced a rise in intracellular calcium. These observations indicate that Ca++ may play a role as a messenger in the activation of human B cells via surface Ig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01915.x
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  • 6
    Electronic Resource
    Electronic Resource
    Adhesion of Subsets of Human Blood Mononuclear Cells to Endothelial Cells In Vitro, as Quantified by Flow Cytometry (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 36 (1992), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Binding of leucocytes to endothelial cells (EC) is essential as an initial step in inflammatory responses. We present a rapid, non-radioactive method to measure adhesion of human lymphoid cells to EC using flow cytometry. Freshly isolated peripheral blood mononuclear cells (PBMC) were allowed to adhere to EC grown in 24-well plates. Non-adhering cells were removed, after which adhering cells and EC were dissociated using trypsin/EDTA. These samples were subsequently analysed by flow cytometry, using scatter properties to distinguish between adhering cells and EC. The ratio of the number of adhering leucocytes and EC was calculated to quantify adhesion. Results of the flow cytometric adhesion assay were comparable to those obtained with a conventional adhesion assay using chromium-labelled cells. We additionally show that by using the flow cytometric adhesion assay, adhesion of lymphocyites and monocytes present within the adhering PBMC can be quantified simultaneously. As a model, the contribution of LFA-1 (CD11a,CD18) and ICAM-1 (CD54) in adhesion of PBMC to EC was studied. It was found that adhesion of lymphocytes and monocytes is regulated differently by phorbol ester and that the relative contribution of LFA-1 and ICAM-1 differs for both cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1992.tb03141.x
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  • 7
    Electronic Resource
    Electronic Resource
    Phenotypical and Functional Characterization of the Idiotype-Positive Blood B Cells in Multiple Myeloma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 28 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study the idiotype-positive B cells of one patient with smouldering multiple mycloma (IgGx) and of one patient with multiple myeloma (IgGλ) were analysed phenotypically and functionally. As regards the expression of B cell-associated differentiation antigen and size distribution, the idiotype-positive B ells resembled normal IgG-bearing blood B Cells. In functional studies the lymphocytes were cultured in vitro with Staphylococcus aureus. pokeweed mitogen, T-cell factors, or combinations of those. After culture, proliferation and differentiation of the idiotype-positive B cells were measured by autoradiography, an idiotype-specific ELISA, and B spot ELISA. The results show that idiotype-positive B Cell of both patients are able to proliferate after simulation in vitro. In contrast to their normal counterparts, however, almost no increase in the amount of secreted idiotypic IgG could be induced. This suggests that the idiotype-positive blood B cells have lost some of their ability to respond to exogenous stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb01513.x
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  • 8
    Electronic Resource
    Electronic Resource
    Generation of High-Rate Ovalbumin-Specific Antibody-Secreting Cells in Cultures of Human Peripheral Blood B Cells Obtained from Non-Immunized Blood Donors (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 28 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: When human peripheral him id B cells are cultured for 6 days with the T cell-dependent peptide antigen ovalbumin (OA) in the presence of antigen-presenting cells and helper T cells, plaque-forming cells (PFC) are generated. These OA-induced PFC differ from the conventional high-rate antibody-secreting PFC formed after stimulation of B cells with recall antigens (e.g. tetanus toxoid) in that they secrete antibody at a very low level. Previous studies have shown that OA-induced PFC are B lymphocytes in an early activation stale rather than cells that have differentiated into plasmablasts. The apparent arrest in the maturation of OA-induced PFC in an early activation phase can he overcome by simultaneous stimulation with interleukin 2 (1L-2) and gamma interferon (IFN-γ). The isotype of the OA-specific antibodies secreted, however, are only of the IgM class, demonstrating that an isotype switch docs not occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb01490.x
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  • 9
    Electronic Resource
    Electronic Resource
    Calcium Ionophore A23187 Induces Interleukin 2 Reactivity in Human T Cells (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 22 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the present study the activation of purified human T lymphocytes by the calcium ionophore A23187 was analysed in the light of current concepts of receptor-linked inositol lipid metabolism. It was found that A23187 was only slightly mitogenic, with a narrow optimum at 400-500 nM. The proliferation could be blocked by anti-Tac ascites at 10-3 dilution, suggesting an interleukin 2 (IL-2)-dependent pathway of activation. However, an unexpectedly large proportion of A23187-stimulated cells expressed the IL-2 receptor. Reculturing the cells with exogenous IL-2 after removal of A23187 resulted in strongly enhanced proliferation. Phorbol myristic acetate (PMA) at non-mitogenic concentrations exerted an extremely strong synergistic effect on A23187-induced cell proliferation, which was, again, mediated via an IL-2-dependent pathway. Supernatants of A23187-stimulated T cells did not contain detectable amounts of IL-2. Combination of PMA and A23187 resulted in considerable IL-2 production. It is concluded that A23187 induces the expression of IL-2 receptors without concurrent stimulation of IL-2 production, thus allowing only low levels of proliferation. Addition of exogenous IL-2 or of PMA restores the imbalance between the occurrence of IL-2 and its receptor and results in high rates of proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01925.x
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  • 10
    Electronic Resource
    Electronic Resource
    Ovalbumin-Specific Human B-Cell Activation and Maturation (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 28 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: By means of a panel of monoclonal antibodies it is demonstrated that, in cultures of human peripheral blood mononuclear cells (PBMC) with the T-cell dependent (TD) antigen ovalbumin (OA), responding B ceils are activated from the resting Mate The differentiation of the activated B cells to high rate-secreting plasma blasts, however, is attested in an early activation phase, in which they can be detected at low rate-secreting plaque-forming cell. The arrest does not occur when stimulation with OA occurs in the presence of antigen-nonspecific activation and maturation factors, which are provided in the culture by the anamnestic response to the TD antigen tetanus toxoid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02414.x
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