ISSN:
1440-1797
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary: Recent progress of genetic engineering allows us to create animal models expressing the new genetic phenotype and also indicates a sure future for clinical use of gene therapy. We applied HVJ-liposome method for manipulation of transforming growth factor (TGF)-β gene expression in anti-Thy-1 experimental glomerulonephritis. Either the glomerular introduction of TGF-β antisense oligodeoxynucleotides or transfection of gene for decorin, a natural inhibitor of TGF-β, into the skeletal muscle could suppress the extracellular matrix (ECM) expansion in glomerulonephritis. Thus, these results may suggest the potential of gene therapy as a novel treatment for fibrotic diseases caused by TGF-β.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1797.1997.tb00296.x