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  • Artikel: DFG Deutsche Nationallizenzen  (23)
  • Digitale Medien  (23)
  • 1995-1999  (20)
  • 1975-1979  (3)
  • 1960-1964
  • 1999  (8)
  • 1996  (12)
  • 1977  (3)
  • 1
    Digitale Medien
    Digitale Medien
    3′,5′-Cyclic Guanosine Monophosphate Activates Mitogen-Activated Protein Kinase in Rat Pinealocytes (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract : The role of 3′,5′-cyclic guanosine monophosphate (cGMP) in the activation of mitogen-activated protein kinases (MAPKs) was investigated in rat pinealocytes. Treatment with dibutyryl cGMP (DBcGMP) dosedependently increased the phosphorylation of both p44 and p42 isoforms of MAPK. This effect of DBcGMP was abolished by PD98059 (a MAPK kinase inhibitor), H7 (a nonspecific protein kinase inhibitor), and KT5823 [a selective cGMP-dependent protein kinase (PKG) inhibitor]. Elevation of cellular cGMP content by treatment with norepinephrine, zaprinast (a cGMP phosphodiesterase inhibitor), or nitroprusside was effective in activating MAPK. Natriuretic peptides that were effective in elevating cGMP levels in this tissue were also effective in activating MAPK. Our results indicate that, in this neuroendocrine tissue, the cGMP/PKG signaling pathway is an important mechanism used by hormones and neurotransmitters in activating MAPK.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730598.x
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  • 2
    Digitale Medien
    Digitale Medien
    Primary low cerebrospinal fluid pressure syndrome with galactorrhea: findings at MR imaging (1996)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 16 (1996), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A case of primary low cerebrospinal fluid (CSF) pressure syndrome with galactorrhea is reported. Magnetic resonance imaging demonstrated diffusely enhanced meninges, edematous brain, and enlarged pituitary gland. Coincidental enlargement of pituitary gland and edematous brain due to low CSF pressure compressed the pituitary portal system. The 1ow-perfused anterior lobe of pituitary gland would be the mechanism of galactorrhea.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1996.1602124.x
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  • 3
    Digitale Medien
    Digitale Medien
    ANTIARRHYTHMIC PROPERTIES OF 5-(3-TERT-BUTYLAMINO-2-HYDROXY)PROPOXY-3,4-DIHYDRO-CARBOSTYRIL HYDROCHLORIDE (OPC- 1085), A NEWLY SYNTHESIZED, POTENT β-ADRENORECEPTOR ANTAGONIST (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The antiarrhythmic properties of 5–(3-tert-butylarnino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085) were compared with those of propranolol and pindolol using various kinds of preparations for experimental arrhythmia in dogs.2. Although OPC-1085 was the most potent drug to antagonize adrenaline-induced arrhythmia in animals anaesthetized with either pentobarbitone sodium or halothane, it was scarcely effective on ouabain-induced arrhythmia in pentobarbitone sodium anaesthetized animals.3. When these compounds were administered intravenously to conscious dogs 24 h after two-stage ligation of the anterior descending artery, ectopic ventricular beats of coronary ligation-induced arrhythmia were reduced while regular sinus beats were simultaneously increased.4. OPC-1085 was very effective on aconitine-induced arrhythmia in dogs anaesthetized with pentobarbitone sodium. The effective dose was similar to that of propranolol but about fifteen times less than that of pindolol.5. It is concluded that different potencies among these β-adrenoreceptor antagonists against various kinds of experimental arrhythmias cannot be simply deduced from any one of the following properties; β-adrenoreceptor antagonism, intrinsic myocardial stimulation, local anaesthetic and so-called quinidine-like effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02684.x
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  • 4
    Digitale Medien
    Digitale Medien
    Merkel cells participate in the induction and alignment of epidermal ends of arrector pili muscles of human fetal skin (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The follicular proximal ends of arrector pili muscles anchor the bulge areas of human hair follicles. However, the location of the ends of these muscles towards the epidermis, especially the fine points of attachment, is not fully understood. Conventional serial sections of the scalp skin of a 12-month-old infant were examined. Most of the distal ends were situated in the upper dermis. while some seemed to be in close contact with the epidermal basal layers. In vertical sections of the scalp skin of 16-week-old fetus, double immunoenzyme staining showed a close topographic correlation between the epidermal ends of the arrector pili muscles and the epidermal and dermal Merkel cells. These findings allow speculation that fetal Merkel cells participate in the induction and alignment of arrector pili muscles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.37788.x
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  • 5
    Digitale Medien
    Digitale Medien
    Serum theophylline concentration levels and preventative effects on exercise-induced asthma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb01142.x
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  • 6
    Digitale Medien
    Digitale Medien
    Specific detection of anti-cell surface antibodies in herpes gestationis sera (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 5 (1996), S. 0 
    Details
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract We examined 42 herpes gestationis sera with immunofluorescence of normal human skin sections, and found that anti-keratinocyte cell surface antibodies were detected specifically in 10 herpes gestationis sera. The diagnosis of these herpes gestationis cases was confirmed by detecting antibodies against the 180 kD bullous pemphigoid antigen with immunoblotting of its fusion protein. The results of immunoadsorption assay using baculoproteins of both pemphigus vulgaris and pemphigus foliaceus antigens indicated that the herpes gestalionis sera did not recognize common pemphigus antigens. Immunoblotting of human epidermal extracts and immunofluorescence of various tissues also suggested that the sera did not recognize any other desmosomal components or paraneoplastic pemphigus antigens. The significance of this reactivity is unclear. However, because no control bullous pemphigoid sera showed this reactivity, it may suggest a different pathophysiology between herpes gestationis and bullous pemphigoid.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0625.1996.tb00101.x
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  • 7
    Digitale Medien
    Digitale Medien
    Unilateral facial angiofibromas—a segmental form of tuberous sclerosis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Multiple facial angiofibroma are thought to be a pathognomonic and common, feature of tuberous sclerosis. In contrast, it is rare to see multiple angiofibroma limited to one side of the face. We have studied a patient with multiple angiofibroma of one cheek, in order to search for other manifestations of tuberous sclerosis and to determine the histochemical identity of the angiofibroma. No evidence of other pathology known to be associated with the tuberous sclerosis complex was uncovered. Histopathology of the unilateral lesions revealed focal fibroplasias and positive cellular staining for factor XIIIa and vimentin similar to that described for bilateral angiofibroma. We suggested that the segmental expression of tuberous sclerosis, in the form of unilateral facial angiofibroma may result from a postzygotic mutation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.110799.x
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  • 8
    Digitale Medien
    Digitale Medien
    Cutaneous Pneumocystis carinii and Cryptococcus neoformans in AIDS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary A patient with AIDS was found to have skin lesions which contained the organisms Pneumocystis carinii and Cryptococcus neoformans. Both organisms were identified using haematoxylin and eosin. Gomori methenamine silver. Giemsa and mucicarmine stains. Electron microscopy was performed and confirmed their presence. The clinical presentation, histopathology, differential diagnosis and treatment of cutaneous P. carinii and C. neoformans in AIDS is presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-753.x
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  • 9
    Digitale Medien
    Digitale Medien
    Anodically deposited manganese-molybdenum oxide anodes with high selectivity for evolving oxygen in electrolysis of seawater (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 769-775 
    Details
    ISSN: 1572-8838
    Schlagwort(e): anodic deposition ; manganese-molybdenum oxide electrode ; oxygen evolution ; seawater electrolysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Manganese-molybdenum oxide electrodes were prepared by anodic deposition on an IrO2-coated titanium substrate at a constant current density of 600Am−2 from baths containing 0.2M MnSO4 and 0–0.1M Na2MoO4 at 90∘C and pH 0.5. These electrodes were characterised for oxygen evolution in the electrolysis at 1,000Am−2 in 0.5M NaCl solution at 30∘C and pH 8 or 12. The most active and stable oxygen evolving anode exhibited 100% efficiency for oxygen evolution, and an efficiency of 98.5% for over 1,500 h at pH 12 and of 96.5% for over 2,800 h at pH 8 of continuous electrolysis. X-ray diffraction measurement and XPS analysis indicated that the deposits consist of a nanocrystalline single γ-MnO2 type phase, and manganese and molybdenum in the deposits are in the Mn4+ and Mo6+ states. The electrochemical studies showed that the manganese-molybdenum oxide electrodes drastically reduced the electrocatalytic activity for chlorine evolution to the undetectable level, resulting in 100% efficiency for oxygen evolution, although the addition of molybdenum slightly increased the oxygen overpotential.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1003492009263
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  • 10
    Digitale Medien
    Digitale Medien
    Linkages between chromophore and apoprotein in the biliverdin-protein of the scales of big blue parrotfish, Scarus gibbus Rüppell (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 583-584 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary On the basis of the amino acid composition of the chromophore peptides, it can be assumed that Asp, Ser and 1/2 Cys are located near the biliverdin chromophore. Experiments for splitting of the chromophore lead us to expect a thioether bond in the linkages between biliverdin and apoprotein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01946509
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