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  • Articles: DFG German National Licenses  (4)
  • Electronic Resource  (4)
  • Endogenous digitalis-like factor  (2)
  • Slow hemodialysis  (2)
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  • Articles: DFG German National Licenses  (4)
Material
  • Electronic Resource  (4)
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Dissociation of digoxin-like immunoreactivity and Na+,K+-ATPase inhibitory activity in rat plasma (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 992-993 
    Details
    ISSN: 1420-9071
    Keywords: Endogenous digitalis-like factor ; digoxin-like immunoreactivity ; Na+,K+-ATPase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We measured endogenous digitalis-like factor (EDF) in rat plasma during acute saline infusion by two different procedures. Na+,K+-ATPase inhibitory activity in the rat plasma significantly increased during saline loading (7.8±2.2 vs 2.5±0.9%, with and without acute saline loading, respectively, p〈0.05). On the other hand, the plasma digoxin-like immunoreactivity significantly decreased during acute saline loading (16.9±1.6 vs 32.0±2.8 pg digoxin equivalents/ml. with and without acute saline loading, respectively, p〈0.01). These results indicate that the major substances detected by digoxin-like immunoreactivity and direct Na+,K+-ATPase inhibitory activity are completely different, at least in rat plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939897
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Further evidence for the dissociation of digoxin-like immunoreactivity from Na+, K+-ATPase inhibitory activity (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 1041-1043 
    Details
    ISSN: 1420-9071
    Keywords: Endogenous digitalis-like factor ; digoxin-like immunoreactivity ; Na+, K+-ATPase inhibitor ; adrenalectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of adrenalectomy or nephrectomy, carried out one hour previously, on the levels of endogenous digitalis-like factors were determined in rat plasma. Factors were assayed by digoxin-like immunoreactivity and direct Na+, K+-ATPase inhibitory activity. Digoxin-like immunoreactivity significantly decreased one hour after bilateral ablation of adrenals, while Na+, K+-ATPase inhibitory activity remained unaltered. There were no changes in either activity one hour after bilateral nephrectomy. These results suggest that digoxin-like immunoreactivity may be derived from the adrenal gland or under adrenal control and the major substances detected by digoxin-like immunoreactivity and direct Na+, K+-ATPase inhibitory activity may be different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940667
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of single-dose intravenous amikacin in critically ill patients undergoing slow hemodialysis (1995)
    Springer
    Intensive care medicine 21 (1995), S. 348-351 
    Details
    ISSN: 1432-1238
    Keywords: Amikacin ; Pharmacokinetics ; Slow hemodialysis ; Renal failure ; Critically ill patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The pharmacokinetics of amikacin were studied in patients undergoing slow hemodialysis (HD). Design Slow HD was performed at the dialysate flow rate of 30 ml/min. After a single intravenous dose of amikacin 5 mg/kg, pharmacokinetic variables were calculated by fitting indivdual concentration-time curves to a two-compartment open model. Patients 6 critically ill patients with renal failure were entered into the study. Results The volume of distribution was 0.35±0.03 l/kg. Total body clearance was 35.1±2.3 ml/min with an elimination half-life of 10.5 h. During a 10.5 h session of slow HD, the serum amikacin concentration decreased from the peak level of 21.3±1.2 mg/l to 7.2±0.9 mg/l. Conclusion Slow HD eliminate amikacin more efficiently than other types of slowly performed renal replacement therapy and had profound effects on the pharmacokinetics. Amikacin elimination by this approach should be taken into consideration for designing a dosage schedule during the treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705414
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Amino acid losses and nitrogen balance during slow diurnal hemodialysis in critically ill patients with renal failure (1997)
    Springer
    Intensive care medicine 23 (1997), S. 110-113 
    Details
    ISSN: 1432-1238
    Keywords: Key words Amino acid ; Nitrogen balance ; Slow hemodialysis ; Critically ill ; Renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The effects of slow diurnal hemodialysis (slow HD) on amino acid losses and nitrogen balance were studied. Design: Slow HD was conducted for 10 h during the day at the dialysate flow rate of 30 ml/min. The patients received total parenteral nutrition including 40 g of amino acids (6.08 g of nitrogen). The amino acid concentrations in plasma and dialysate were determined and the daily nitrogen balance was calculated from the urea nitrogen appearance. Patients: Six critically ill patients with renal failure were entered into the study. Results: Slow HD eliminated 48.5±4.4 mmol (6.2±0.6 g) of amino acids, representing 16% of the daily amino acid load. The estimated nitrogen balance was –2.3±1.3 g/day. Amino acid nitrogen lost in the dialysate was 1.0±0.1 g, contributing 43% of the daily negative nitrogen balance. Conclusion: The amount of amino acid losses during slow HD should be taken into consideration when designing nutritional schedules for maintaining positive nitrogen balance in critically ill patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050299
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    Paper (German National Licenses)
    Fulltext
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